CESLab 3.0
SingleCable Bench Series Technical Specifications

1. Introduction

ECG Viewer window showing output generated by the activation of the right terminal in this Preparation. The ECG deflection sensitivity used here is 25 nV/mm, much smaller than that used for standard ECG's on biological hearts, since the body surface potentials generated by the low number of Cells in this Preparation are relatively weak. The cable is in its initial horizontal (unrotated) orientation, so the tracings indicate activation proceeding directly right to left along the cable. Click on image to enlarge.

2. Bench Component Objects

2.1. Tissue Types

• Right Tissue Type

  This tissue type is used for the Cells in the rightmost (from the point of view of the Preparation) section of the conductive cable.

  Tissue type window for "Right Tissue Type". Activation waveform is similar to that of ventricular myocardial tissue according to Katz. Click on image to enlarge.

• Middle Tissue Type

  This tissue type is used for the Cells in the middle section of the conductive cable.

• Left Tissue Type

  This tissue type is used for the Cells in the leftmost (from the point of view of the Preparation) section of the conductive cable.

2.2. Subtissues

• Left Segment

  This subtissue makes up the leftmost (from the Preparation's point of view) portion of the simulated cable.

• Middle Segment

  This subtissue makes up the middle portion of the simulated cable.

• Right Segment

  This subtissue makes up the rightmost (from the Preparation's point of view) portion of the simulated cable.

• Left Terminal

  This subtissue is an excitable node located at the left end of the Preparation, initially deactivated.

• Middle Terminal

  This subtissue is an excitable node located in the middle of the Preparation, initially deactivated.

• Right Terminal

  This subtissue is an excitable node located at the right end of the Preparation. It is initially specified as active and automatic.

2.3. Modulators

• Stimulant X

  This drug has effects in every modality, including increased action potential magnitude, decreased action potential duration, and increased automaticity.

  Modulator Effect Editor window showing selected Modulator Effect Modalities for "Stimulant X". Click on image to enlarge.

• Middle Phase 2 Prolonger

  This simulated drug effects only Cells associated with "Middle Tissue Type", and has the single effect of increasing the duration of activation phase 2.

2.4. Matrices

2.5. Cell Sets

Cell Set Viewer window showing a diagrammatic view of cell set "Myocardial CellSet". Click on image to enlarge.

2.6. Bench Scripts

• Bench Initialization Script

  This script is executed whenever the Bench is opened, and defines a BenchFun to remap fractional depths (though none exist for this Preparation).

• Demo Drug Modelling

  This script executes a simple demonstration of drug modelling in this Preparation by running a set of Trials at increasing concentrations of drug "Stimulant X".

  Electrogram Viewer window after execution of script "Demo Drug Modelling". Top tracing is for a Cell at the right end of the Preparation, middle tracing for a Cell at the middle, bottom tracing for a Cell at the left end of the cable. The effect of increasing serum concentrations of "Stimulant X" is evident as increased conduction speed, increased action potential magnitudes, and decreased activation waveform duration. Click on image to enlarge.

• Demo Decremental Conduction

  This script is intended to demonstrate the effect of enabling decrementation conduction in this Bench. Its effects are best seen in an electrogram window showing tracings for different positions along the Preparation cable.

  Electrogram Viewer window after execution of script "Demo Decremental Conduction". Top tracing is for a Cell at the right end of the Preparation, middle tracing for a Cell at the middle, bottom tracing for a Cell at the left end of the cable. The effect of enabled decremental conduction is to cause the third activation (which follows the second relatively closely) to be conducted to the left end of the cable more slowly than the second activation. Click on image to enlarge.

• Demo 3:2 Conduction Block

  A script intended to demonstrate 3:2 (and indirectly, more complex) conduction blockage in this Preparation.

  Electrogram Viewer window after execution of script "Demo 3:2 Conduction Block". Top tracing is for a Cell at the right end of the Preparation, middle tracing for a Cell at the middle, bottom tracing for a Cell at the left end of the cable. The script operates by using drug "Middle Phase 2 Prolonger" to increase the action duration of the middle of the cable, and then rapidly stimulating the right terminal with a regular succession of pulses. The impulses are successfully conducted to the middle subtissue, but it has not always recovered sufficiently to accept the impulse, so period blockage occurs. In turn, its action duration is high enough to restimulate the left end of the cable, displaying more complex (e.g. 4:3) second-order blockage at that end. Click on image to enlarge.

• Demo Interval/Duration Effects

  This script demonstrates interval/duration effects by running a series of Trials with varying interactivation intervals.

  Electrogram Viewer window after execution of script "Demo Interval/Duration Effects". Top tracing is for a Cell at the right end of the Preparation, middle tracing for a Cell at the middle, bottom tracing for a Cell at the left end of the cable. The effect of decreasing the interval between the first and second activations is evident as decreased action duration in the second waveform. Click on image to enlarge.

• Demo Interval/Potential Effects

  This script demonstrates interval/potential effects by running a series of Trials with varying interactivation intervals.

  Electrogram Viewer window after execution of script "Demo Interval/Potential Effects". Top tracing is for a Cell at the right end of the Preparation, middle tracing for a Cell at the middle, bottom tracing for a Cell at the left end of the cable. The effect of decreasing the interval between the first and second activations is evident as decreased action potentials in the second waveform. Click on image to enlarge.